Information and guidance on treatment add-ons for clinics

The HFEA and the professional and patient bodies that are the signatories to the consensus statement on the responsible use of treatment add-ons in fertility services have put together the following list of freely available resources from their respective organisations and the Cochrane Library. These resources can be used to support conversations with patients about add-ons.

Treatment add-ons in general

British Fertility Society (BFS) Quick guide

Assisted hatching

Cochrane Review

Endometrial scratching/injury

Cochrane Review

Glucocorticoids/Steroids

Cochrane Review

Hyaluronate enriched medium

Cochrane Review

Intracytoplasmic morphologic sperm injection (IMSI)

Cochrane Review

Pre-implantation genetic testing for aneuploidy (PGT-A)

Cochrane Review

Practice Committees for the American Society for Reproductive Medicine (ASRM) & the Society for Assisted Reproductive Technology (SART): a review and opinion on the use of PGT-A

European Society of Human Reproduction and Embryology (ESHRE) have published 3 papers describing good practice recommendations relating to PGT-A:

Good practice recommendations for organisation of a PGT centre

Recommendations on the technical aspects of polar body and embryo biopsy for PGT

Recommendations on the technical aspects of PGT for chromosomal structural rearrangements (PGT-SR) and PGT for aneuploidies (PGT-A)

Time-lapse imaging  

BFS Quick Guide

Cochrane Review

ESHRE guidelines